ea0020p567 | Neuroendocrinology, Pituitary and Behaviour | ECE2009
Quintela Telma
, Alves Henrique
, Goncalves Isabel
, Baltazar Graca
, Santos Cecilia
Transthyretin (TTR) is a protein mainly synthesized by the liver and choroid plexus (CP) of the brain. Besides its role as a carrier for thyroid hormones, TTR also sequesters the amyloid beta (Aβ) peptide impairing its deposition in nervous tissues, and its concentrations in the cerebrospinal fluid (CSF) appear to be inversely correlated with Alzheimers disease (AD) onset and progression. Abundant evidence suggests that the depletion of progesterone (PROG) at menopa...